Turned professional in 2016 after an eye-catching performance at the Masters Tournament, when he finished in a share of 21st as the defending U.S Amateur Champion. He then claimed a top 15 finish at that year's U.S. Open.

Won his first PGA TOUR title in 2017 at the John Deere Classic and went on to win four times in 2018 as he earned a debut appearance for the United States at The Ryder Cup at Le Golf National as one of Jim Furyk’s Captain’s Picks.

Lifted his first DP World Tour trophy in 2019 with a commanding seven shot victory at the Omega Dubai Desert Classic, where he set a new tournament record score with a 24 under par total.

Underwent a major physical transformation in preparation for the 2020 season, which yielded a maiden Major Championship at the U.S. Open at Winged Foot. DeChambeau was the only player under par as he romped to a six-stroke victory.

Claimed his second Major Championship in 2024 at the U.S. Open at Pinehurst, finishing one stroke ahead of Rory McIlroy.